Award-winning cellular repair therapy | Treat dark circles, fine lines & crepey skin | Salmon DNA bio-stimulator | Polynucletoides on the Wirral
Treatment Overview
From £240
30-45 minutes
Minimal
6-9 months
WHY CHOOSE AESTHETICS BY DR RACHEL?
When skincare alone is no longer delivering results, when the under-eye area appears persistently tired, or when the skin feels thinner and less resilient, polynucleotides offer a different approach. Rather than masking concerns, they work at a cellular level to support repair, strengthen skin structure and improve overall skin quality. This is a regenerative treatment designed to restore the skin’s underlying health and function, helping it behave more like younger skin over time rather than offering a short-term cosmetic effect.
Polynucleotides are highly purified DNA fragments originally isolated from salmon, chosen for their close biological compatibility with human skin. They work by activating fibroblasts - the cells responsible for producing collagen, elastin and hyaluronic acid. Rather than adding volume or acting only at the surface, polynucleotides support the skin’s natural repair processes from within. Over the following 12 weeks, the skin gradually rebuilds itself, leading to improved strength, elasticity and overall skin quality in a natural, progressive way.
Polynucleotides are particularly helpful for concerns driven by skin quality rather than volume, such as dark circles caused by thin under-eye skin, crepey skin texture, menopausal skin thinning associated with hormonal change, acne scarring that requires tissue remodelling, and even certain forms of hair loss. By supporting repair at a cellular level, polynucleotides help improve skin strength, resilience and function in areas where other approaches may be limited.
Results develop gradually as the skin regenerates, creating improvements that look subtle and natural rather than sudden or artificial. Over time, the skin becomes thicker, firmer, better hydrated and more resilient. Patients are often told they look rested or refreshed, without it being obvious that they have had treatment. Polynucleotides align beautifully with my philosophy of refreshed, never changed, enhancing skin quality in a way that looks natural, gradual and never overdone.
Polynucleotides have been used in regenerative medicine for many years and are highly biocompatible with human tissue. These purified DNA fragments are well tolerated and integrate naturally within the skin, with a low risk of adverse reactions when used appropriately. When administered by qualified medical professionals with detailed anatomical knowledge, polynucleotide treatments offer a high level of safety alongside meaningful, regenerative skin improvement.
Polynucleotides are highly purified DNA fragments derived from salmon, selected for their close biological compatibility with human skin. They work at a cellular level to support the skin’s natural repair processes, strengthening tissue and improving skin quality from within. This is a regenerative treatment that focuses on restoring skin health, rather than simply treating the surface.
"Every time I explain polynucleotides to patients, I often see a lightbulb moment. For many people, this treatment offers something that other aesthetic approaches cannot.
While many traditional treatments focus on improving visible symptoms, polynucleotides work at a deeper level, supporting one of the key biological drivers of skin ageing: declining cellular function.
As we age, fibroblasts - the cells responsible for producing collagen, elastin and hyaluronic acid - become less active. This contributes to thinning skin, reduced elasticity, dehydration and the tired, crepey appearance that is often most noticeable around delicate areas such as the under-eyes, where treatment options can be limited.
Polynucleotides are highly purified DNA fragments derived from salmon. When carefully injected into human tissue, they encourage fibroblasts to become more active, supporting collagen production, improving microcirculation and helping repair cellular DNA damage caused by UV exposure and oxidative stress. By strengthening the skin from within, they also create a healthier foundation, making them an ideal primer before other collagen-stimulating treatments.
In my clinic, I use premium, CE-marked products such as Plinest, selected for their safety, purity and clinical evidence. A typical course involves 3-4 treatments spaced 3-4 weeks apart, building a regenerative foundation within the skin. Improvements develop gradually, with results becoming most noticeable around 12 weeks as the skin strengthens and renews.
For menopausal skin, where thinning and dryness are influenced by declining oestrogen levels, polynucleotides offer targeted cellular support alongside hormonal management. Many of my Wirral patients in their 40s, 50s and 60s find this approach particularly helpful for restoring skin quality and resilience.
This reflects the direction aesthetic medicine is moving in: supporting the skin to repair and regenerate itself, rather than simply addressing surface changes."
— Dr Rachel Sinton, MBChB (Hons), MRCGP, GMC-Registered GP
"I've had polynucleotides for my under-eyes for six months now and the transformation is incredible. My hereditary dark circles have significantly faded and my skin looks so much healthier. Dr Rachel explained everything thoroughly, and I felt completely confident in her expertise. This has genuinely changed how I feel about my face."
Emma, West Kirby
Polynucleotides
"The under-eye area, where many patients choose polynucleotides, is one of the most delicate and technically demanding areas of the face. The skin is extremely thin, the vascular anatomy is complex, and careful assessment and precise technique are essential to minimise risk and achieve the best outcome.
This is where doctor-led treatment matters.
As a GMC-registered GP with over ten years of clinical experience, I bring medical training, diagnostic expertise and a detailed understanding of facial anatomy to every treatment. I am trained to recognise complications early and manage them appropriately, and just as importantly, to reduce the risk of complications through careful planning, anatomical knowledge and clinical judgement.
I carry emergency equipment and hold full professional indemnity insurance for advanced injectable procedures. However, safety is not only about responding to problems; it is about preventing them. That starts with thorough assessment, correct product choice and precise technique.
Before any treatment, I carry out a comprehensive medical consultation. I assess your skin quality, examine the anatomy around the under-eye area and discuss suitability in detail. In some cases, I may recommend alternative or complementary treatments, such as combining polynucleotides with pHformula medical skincare or microneedling, to support skin health more holistically.
I am also a member of CMAC (Complications in Medical Aesthetics Collaborative), ensuring that my practice remains aligned with the latest safety guidance and evidence-based protocols.
Your face deserves expert care, careful judgement and a medical approach focused on safety as well as results.”
— Dr Rachel Sinton, GMC-Registered GP & CMAC Member
An award-winning, doctor-led aesthetic clinic specialising in natural, regenerative results across the Wirral. Advanced under-eye treatments demand a medical approach, expert assessment and precise technique.
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WHO SHOULD CONSIDER THIS TREATMENT?
Polynucleotides are an ideal option for those seeking genuine cellular repair and long-term improvement in skin quality. They are particularly well suited to concerns linked to skin thinning and reduced resilience, such as dark circles, crepey texture and menopausal skin changes, especially where other treatments may offer more limited benefit.
You have under-eye dark circles caused by thin, translucent skin where underlying blood vessels are visible. Polynucleotides help improve skin thickness and support microcirculation, gradually softening the appearance of these stubborn circles.
You have crepey, thinning skin, especially around the under-eyes, neck or hands. By supporting dermal repair, polynucleotides help improve elasticity and resilience for smoother, stronger skin.
You are experiencing menopausal skin changes related to declining oestrogen, including thinning, dryness and loss of firmness. Polynucleotides help support the cellular processes that are normally influenced by oestrogen, improving skin quality and resilience over time.
You are seeking long-term improvement in skin quality rather than short-term cosmetic fixes, with results that develop progressively over 12 weeks as the skin regenerates.
You are not suitable for dermal fillers in delicate areas such as the under-eyes, or prefer a non-volumising approach. Polynucleotides improve skin quality without adding volume.
You have acne scarring that requires tissue remodelling and collagen support to improve uneven texture and atrophic scars.
✓ Dark circles (related to skin thinning and vascular visibility)
✓ Fine lines and crepey texture
✓ Skin thinning and loss of firmness
✓ Dehydration and dull complexion
✓ Acne scarring and uneven texture
✓ Menopausal skin changes
✓ Hair thinning
✗ Pregnant or breastfeeding
✗ Active skin infection
✗ Autoimmune skin conditions
✗ Unrealistic expectations for immediate results
Real Results
Swipe to reveal the transformation. See the remarkable results our patients have achieved.
Your Questions Answered
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